Prediction of the xanthine oxidase inhibitory activity of celery seed extract from ultraviolet–visible spectrum using machine learning algorithms
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Inhibitory effect of Physalis alkekengi extracts in different phenological stages on xanthine oxidase activity
Introduction: Physalis alkekengi (Solanaceae) is a rich source of various antioxidants. There are some reports that show P. alkekengi has been used for treatment of a wide range of diseases including gout and inflammation. Xanthine oxidase plays a crucial role in gout. Many natural compounds such as various flavonoids have been reported to have inhibitory effect on xanthine oxidase. Metho...
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over production of uric acid by xanthine oxidase (xo) causes gout. xo inhibitors for example allopurinol are the most important available anti gout drugs. medicinal herbs are available natural sources that may be useful for the treatment of gout. in this study the inhibitory activity of aqueous extracts of matricaria chamomilla l., hypericum perforatum l., fraxinus excelsior l., zea mays l., tr...
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Flavonoids could serve as potent inhibitors of xanthine oxidase (XO). In the present study, the effects of Ruta graveolens L. extract and its major isolated flavonoids, quercetin and rutin, on guinea pig liver XO have been investigated. The inhibitory effects of R. graveolens, quercetin and its glycoside form, rutin, were assayed spectrophotometrically. R. graveolens...
متن کاملVirtual Screening Analysis and In-vitro Xanthine Oxidase Inhibitory Activity of Some Commercially Available Flavonoids
Allopurinol, the xanthine oxidase inhibitor, is the only drug available for the treatment of gout. We examined the xanthine oxidase inhibitory activity of some commercially available flavonoids such asepigallocatechin, acacatechin, myricetin, naringenin, daidzein and glycitein by virtual screening and in-vitro studies. The interacting residues within the complex model and their contact types we...
متن کاملVirtual Screening Analysis and In-vitro Xanthine Oxidase Inhibitory Activity of Some Commercially Available Flavonoids
Allopurinol, the xanthine oxidase inhibitor, is the only drug available for the treatment of gout. We examined the xanthine oxidase inhibitory activity of some commercially available flavonoids such asepigallocatechin, acacatechin, myricetin, naringenin, daidzein and glycitein by virtual screening and in-vitro studies. The interacting residues within the complex model and their contact types we...
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ژورنال
عنوان ژورنال: SN Applied Sciences
سال: 2020
ISSN: 2523-3963,2523-3971
DOI: 10.1007/s42452-020-03542-z